Manchester United boss Mourinho, suggested Liverpool and Chelsea would find it difficult to handle the demands of domestic and European football next season.
In response, Klopp pointed out that Liverpool had experienced a hectic schedule, when they reached the Europa League final during his first season in charge at Anfield.
“I’m not interested in what Jose Mourinho says,” he said.
“Why should I talk about Manchester United? Jose is talking about us, yes.
“OK, we had a season like Man United the year before. I don’t know if anybody asked us how it feels. Sorry that we lost the final, yes. We played Sevilla, they played Ajax. That’s the difference.
“So we suffered during the season. The Europa League was hard. Yes, Chelsea will feel also the difference – they played something like 13 players last season. But it’s also not my problem if they use only 11, well done.
“I don’t want to be part of this. I answer if you ask, but I am not interested.”